Pitavastatin calcium ( Itabastatin; Itavastatin; NK 104 )

Catalog No. M12034 CAS No. 147526-32-7

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HNMR

HPLC

MSDS

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Product Name

Pitavastatin calcium
Note

Research use only, not for human use.
Brief Description

Pitavastatin calcium is a novel member of the medication class of statins.
Description

Pitavastatin calcium is a novel member of the medication class of statins. The statins are a family of compounds that inhibit 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase, a pivotal enzyme in cholesterol biosynthesis. Pitavastatin is a potent inhibitor of HMG-CoA reductase (Ki = 1.7 nM). It lowers both total cholesterol and low density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cytochrome P450 system is minimal, reducing the risk of drug-drug interactions. Moreover, pitavastatin causes atherosclerosis regression in humans with subclinical carotid atherosclerosis and improves cardiac function and survival in a rat model of hypertensive heart failure.
Synonyms

Itabastatin; Itavastatin; NK 104
Pathway

Others
Target

Other Targets
Recptor

cholesterol esters
Research Area

Cancer
Indication

——

CAS Number

147526-32-7
Formula Weight

880.98
Molecular Formula

C50H46CaF2N2O8
Purity

>98%(HPLC)
Solubility

DMSO: 51 mg/mL (57.89 mM)
SMILES

C1C(C1)C2=NC3=CC=CC=C3C(=C2/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C4=CC=C(C=C4)F.C1C(C1)C2=NC3=CC=CC=C3C(=C2/C=C/[C@@H](O)C[C@@H](O)CC(=O)[O-])C4=CC=C(C=C4)F.[Ca+2]
Chemical Name

——

1.Ahmad H, et al. Cardiol Rev, 2010, 18(5):264-267.

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